Effects of polyphenol-rich cornelian cherry (Cornus mas L.) and barberry (Berberis vulgaris) fruits extract on reducing in vitro starch digestibility

An evaluation of hydrolysis index



Polyphenols, Cornelian cherry, Barberry, Glycemic index, Nutrition, In vitro


The purpose of this study was to investigate the polyphenol-rich cornelian cherry (Cornus mas L.) and barberry (Berberis vulgaris) fruits extract on reducing the in vitro starch digestibility of white bread and evaluation of glycemic indexes. Generally, all berry fruit types reduced the starch digestibility and predicted glycemic index of white bread. When we evaluated the association between the RDS and HI, the amount of RDS was decreased by the treatments of barberry extract and cornelian cherry extract and the HI of white bread was also decreased. It is thought that the barberry has more inhibitory effects on α-amylase activity than cornelian cherry. We also demonstrated that dietary polyphenols such as anthocyanins and catechins found in cornelian cherry and barberry fruit reduced starch digestion by inhibiting α-amylase and α-glucosidase.


1. Referans1- Lima, A. L., Illing, T., Schliemann, S., & Elsner, P. (2017). Cutaneous manifestations of diabetes mellitus: a review. American Journal of Clinical Dermatology, 18(4), 541-553.
2. Referans2- Nanayakkara, N., Curtis, A. J., Heritier, S., Gadowski, A. M., Pavkov, M. E., Kenealy, T., ... & Zoungas, S. (2021). Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses. Diabetologia, 64(2), 275-287.
3. Referans3- Vlachos, D., Malisova, S., Lindberg, F. A., & Karaniki, G. (2020). Glycemic Index (GI) or glycemic load (GL) and dietary interventions for optimizing postprandial hyperglycemia in patients with T2 diabetes: A review. Nutrients, 12(6), 1561.
4. Referans4- Dereje, N., Bekele, G., Nigatu, Y., Worku, Y., & Holland, R. P. (2019). Glycemic index and load of selected ethiopian foods: an experimental study. Journal of diabetes research, 2019.
5. Referans5- Giuberti, G., Rocchetti, G., & Lucini, L. (2020). Interactions between phenolic compounds, amylolytic enzymes and starch: An updated overview. Current Opinion in Food Science, 31, 102-113.
6. Referans6- Sieri, S., Agnoli, C., Grioni, S., Weiderpass, E., Mattiello, A., Sluijs, I., ... & Krogh, V. (2020). Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study. The American journal of clinical nutrition, 112(3), 631-643.
7. Referans7- Gorji, Z., Modaresi, M., Yekanni-Nejad, S., & Mahmoudi, M. (2020). Effects of low glycemic index/high-fat, high-calorie diet on glycemic control and lipid profiles of children and adolescence with cystic fibrosis: A randomized double-blind controlled clinical trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14(2), 87-92.
8. Referans8- Hanhineva, K., Törrönen, R., Bondia-Pons, I., Pekkinen, J., Kolehmainen, M., Mykkänen, H., & Poutanen, K. (2010). Impact of dietary polyphenols on carbohydrate metabolism. International journal of molecular sciences, 11(4), 1365-1402.
9. Referans9- Sun, L., & Miao, M. (2020). Dietary polyphenols modulate starch digestion and glycaemic level: A review. Critical reviews in food science and nutrition, 60(4), 541-555.
10. Referans10- Capcarova, M., Kalafova, A., Schwarzova, M., Schneidgenova, M., Svik, K., Prnova, M. S., ... & Brindza, J. (2019). Cornelian cherry fruit improves glycaemia and manifestations of diabetes in obese Zucker diabetic fatty rats. Research in veterinary science, 126, 118-123.
11. Referans11- Dzydzan, O., Bila, I., Kucharska, A. Z., Brodyak, I., & Sybirna, N. (2019). Antidiabetic effects of extracts of red and yellow fruits of cornelian cherries (Cornus mas L.) on rats with streptozotocin-induced diabetes mellitus. Food & function, 10(10), 6459-6472.
12. Referans12- Popović, B. M., Blagojević, B., Latković, D., Četojević-Simin, D., Kucharska, A. Z., Parisi, F., & Lazzara, G. (2021). A one step enhanced extraction and encapsulation system of cornelian cherry (Cornus mas L.) polyphenols and iridoids with β-cyclodextrin. LWT, 141, 110884.
13. Referans13- Emamat, H., Asadian, S., Zahedmehr, A., Ghanavati, M., & Nasrollahzadeh, J. (2021). The effect of barberry (Berberis vulgaris) consumption on flow‐mediated dilation and inflammatory biomarkers in patients with hypertension: A randomized controlled trial. Phytotherapy Research, 35(5), 2607-2615.
14. Referans14- Rahimi-Madiseh, M., Lorigoini, Z., Zamani-Gharaghoshi, H., & Rafieian-Kopaei, M. (2017). Berberis vulgaris: specifications and traditional uses. Iranian Journal of Basic Medical Sciences, 20(5), 569.
15. Referans15- Ebrahimi-Mamaghani, M., Arefhosseini, S. R., Golzarand, M., Aliasgarzadeh, A., & Vahed-Jabbary, M. (2009). Long-term effects of processed Berberis vulgaris on some metabolic syndrome components. In Iranian Journal of Endocrinology and Metabolism (Vol. 11, No. 1).
16. Referans16- Kashkooli, R. I., Najafi, S. S., Sharif, F., Hamedi, A., Asl, M. K. H., Kalyani, M. N., & Birjandi, M. (2015). The effect of Berberis vulgaris extract on transaminase activities in non-alcoholic fatty liver disease. Hepatitis monthly, 15(2).
17. Referans17- Safari, Z., Farrokhzad, A., Ghavami, A., Fadel, A., Hadi, A., Rafiee, S., ... & Askari, G. (2020). The effect of barberry (Berberis vulgaris L.) on glycemic indices: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 51, 102414.




How to Cite

Effects of polyphenol-rich cornelian cherry (Cornus mas L.) and barberry (Berberis vulgaris) fruits extract on reducing in vitro starch digestibility: An evaluation of hydrolysis index. (2022). International Journal of Innovative Research and Reviews, 6(1), 1-5. http://www.injirr.com/index.php/injirr/article/view/85