In this study, we aimed to compare the effectiveness of jet nebulizer and oxygen supply connected to the central system with a mask in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). A randomized, prospective, single-center clinical trial was conducted on patients admitted to the emergency department for acute exacerbation of COPD, diagnosed with guidelines provided by Global Initiative for Chronic Obstructive Lung Disease. The patients were randomized into two groups; the first group was applied treatment with jet-nebulizer, and the second group treatment applied with oxygen supply connected to the central system. Vital signs and arterial blood gas parameters were investigated. The mean age of the included 167 patients was 69.9±10 and 66% of them were male. In terms of the effectiveness of the treatments, the respiratory rate, among the vital signs, and pCO2, among the blood gas parameters were statistically decreased in the nebulizer group. Moreover, pO2 and sO2 levels were statistically increased in the nebulizer treatment group compared to the other group. It was found that patients' blood gas parameters significantly improved in treatments applied with nebulizers. Nebulizers should be preferred in the emergency department for the treatment of acute exacerbation of COPD.
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